Important Safety Information
See Important Safety Information, including Boxed Warning, about:

Semaglutide Safety Information

Who Should Not Use Semaglutide

Do not use semaglutide if:

  • You or a family member have ever had medullary thyroid carcinoma (MTC), a type of thyroid cancer.
  • You have a condition called Multiple Endocrine Neoplasia syndrome type 2 (MEN 2).
  • You have had a serious allergic reaction to semaglutide or any of its ingredients.

If you are unsure whether any of these apply to you, speak with your healthcare provider before starting treatment.

How Is Semaglutide Administered

Semaglutide is typically administered as a once-weekly subcutaneous injection.

The medication may be injected into the:

  • Abdomen
  • Thigh
  • Upper arm

It may be taken with or without food. In many treatment plans, the dosage may be gradually adjusted over time depending on your provider’s clinical guidance.

Do not change your dose or stop treatment without first speaking with your healthcare provider.

What Should You Tell Your Provider Before Starting

Semaglutide may interact with other medications. Be sure to tell your provider about all medications and supplements you take, including:

  • Prescription medications
  • Over-the-counter medications
  • Vitamins
  • Herbal or dietary supplements

Certain medications may require additional monitoring, including:

  • Medications used to treat diabetes, including insulin or sulfonylureas
  • Other medications that affect blood sugar levels
  • Other medications used for weight management

Semaglutide may slow stomach emptying, which can affect how some oral medications are absorbed.

Medical History to Discuss With Your Provider

Tell your provider if you have ever had:

  • Type 1 or Type 2 diabetes
  • Thyroid cancer
  • Pancreatitis
  • Kidney disease
  • Gallbladder disease
  • Diabetic eye disease
  • Depression or other mental health conditions
  • Suicidal thoughts or behaviors

Sharing your full medical history helps ensure the safest treatment plan.

Pregnancy and Breastfeeding

Tell your provider if you are:

  • Pregnant
  • Planning to become pregnant
  • Breastfeeding

Semaglutide should not be used during pregnancy, as weight loss during pregnancy may pose risks to an unborn baby.

Because semaglutide may remain in the body for an extended period, treatment is typically discontinued at least two months before a planned pregnancy.

If you are breastfeeding or planning to breastfeed, discuss the best feeding options with your provider before starting treatment.

Important Safety Information

Seek immediate medical care if you experience symptoms of a serious reaction.

Thyroid Tumors

Studies in animals showed an increased risk of thyroid tumors. It is not known whether this occurs in humans.

Contact your provider if you experience:

  • A lump or swelling in the neck
  • Hoarseness
  • Difficulty swallowing
  • Shortness of breath

Pancreatitis

Inflammation of the pancreas may occur.

  • Severe abdominal pain that does not go away
  • Pain that may radiate to the back
  • Vomiting

Gallbladder Problems

Semaglutide may increase the risk of gallstones or other gallbladder conditions.

  • Upper abdominal pain
  • Fever
  • Yellowing of the skin or eyes
  • Clay-colored stools

Low Blood Sugar (Hypoglycemia)

Low blood sugar may occur, particularly in patients who also take medications that lower blood sugar.

  • Dizziness
  • Sweating
  • Fast heartbeat
  • Blurred vision
  • Mood changes

Kidney Problems

Severe nausea, vomiting, or diarrhea can lead to dehydration and may worsen kidney function in some individuals.

Serious Allergic Reactions

Stop using the medication and seek medical attention immediately if you experience:

  • Swelling of the face, lips, tongue, or throat
  • Severe rash or itching
  • Trouble breathing or swallowing
  • Fainting or dizziness

Eye Problems in Patients With Diabetes

Contact your provider if you notice changes in vision.

Increased Heart Rate

Notify your provider if you experience a rapid heartbeat while at rest.

Mood or Behavioral Changes

Contact your provider if you experience new or worsening changes in mood or behavior.

Never Share Injection Devices

Do not share injection pens or syringes with another person. Sharing devices may increase the risk of infection.

Most Common Side Effects

  • Nausea
  • Diarrhea
  • Vomiting
  • Constipation
  • Stomach discomfort
  • Indigestion
  • Injection site reactions
  • Fatigue
  • Belching
  • Hair thinning
  • Heartburn

These effects are often mild to moderate and may decrease as your body adjusts to treatment.

Important Treatment Instructions

  • Your provider should show you how to administer the injection before your first dose.
  • Use the medication exactly as prescribed.
  • Inject once per week on the same day each week.
  • Rotate injection sites each week.

If too much medication is taken, seek medical advice promptly or contact a poison control center.

Learn More

This summary provides general information about semaglutide but does not include all available information about this medication.

Always follow the guidance of your healthcare provider and review the medication information provided with your prescription.

Your provider can help determine whether this treatment is appropriate for you.



Tirzepatide Safety Information

Who Should Not Use Tirzepatide

Do not use tirzepatide if:

  • You or a family member have ever had medullary thyroid carcinoma (MTC), a type of thyroid cancer.
  • You have a condition called Multiple Endocrine Neoplasia syndrome type 2 (MEN 2).
  • You have had a serious allergic reaction to tirzepatide or any of its ingredients.

If you are unsure whether any of these apply to you, speak with your healthcare provider before starting treatment.

How Is Tirzepatide Administered

Tirzepatide is typically administered as a once-weekly subcutaneous injection.

The medication may be injected into the:

  • Abdomen
  • Thigh
  • Upper arm

It may be taken with or without food. In many treatment plans, the dosage may be gradually adjusted over time depending on your provider’s clinical guidance.

Do not change your dose or stop treatment without first speaking with your healthcare provider.

What Should You Tell Your Provider Before Starting

Tirzepatide may interact with other medications. Be sure to tell your provider about all medications and supplements you take, including:

  • Prescription medications
  • Over-the-counter medications
  • Vitamins
  • Herbal or dietary supplements

Certain medications may require additional monitoring, including:

  • Medications used to treat diabetes, including insulin or sulfonylureas
  • Other medications that affect blood sugar levels
  • Other medications used for weight management

Tirzepatide may slow stomach emptying, which can affect how some oral medications are absorbed.

If you take oral medications where timing is important, your provider can guide you on how to schedule them.

Medical History to Discuss With Your Provider

Tell your provider if you have ever had:

  • Type 1 or Type 2 diabetes
  • Thyroid cancer or thyroid nodules
  • Pancreatitis
  • Kidney disease
  • Gallbladder disease
  • Diabetic eye disease
  • Severe stomach or intestinal problems (including slowed stomach emptying)
  • Depression or other mental health conditions
  • Suicidal thoughts or behaviors

Sharing your full medical history helps ensure the safest treatment plan.

Pregnancy and Breastfeeding

Tell your provider if you are:

  • Pregnant
  • Planning to become pregnant
  • Breastfeeding

Tirzepatide should not be used during pregnancy, as weight loss during pregnancy may pose risks to an unborn baby.

Because tirzepatide may remain in the body for an extended period, treatment is typically discontinued well in advance of a planned pregnancy. Follow your provider’s guidance on timing.

If you are breastfeeding or planning to breastfeed, discuss the best feeding options with your provider before starting treatment.

Important Safety Information

Seek immediate medical care if you are experiencing a medical emergency.

Thyroid Tumors

Studies in animals showed an increased risk of thyroid tumors. It is not known whether this occurs in humans.

Contact your provider if you experience:

  • A lump or swelling in the neck
  • Hoarseness
  • Difficulty swallowing
  • Shortness of breath

Pancreatitis

Inflammation of the pancreas may occur.

Contact your provider right away if you experience:

  • Severe abdominal pain that does not go away
  • Pain that may radiate to the back
  • Vomiting

Gallbladder Problems

Tirzepatide may increase the risk of gallstones or other gallbladder conditions.

Contact your provider if you experience:

  • Upper abdominal pain
  • Fever
  • Yellowing of the skin or eyes
  • Clay-colored stools

Low Blood Sugar (Hypoglycemia)

Low blood sugar may occur, particularly in patients who also take medications that lower blood sugar.

Symptoms may include:

  • Dizziness
  • Sweating
  • Fast heartbeat
  • Blurred vision
  • Mood changes

Kidney Problems

Severe nausea, vomiting, or diarrhea can lead to dehydration and may worsen kidney function in some individuals. Stay well hydrated and contact your provider if symptoms persist.

Serious Allergic Reactions

Stop using the medication and seek medical attention immediately if you experience:

  • Swelling of the face, lips, tongue, or throat
  • Severe rash or itching
  • Trouble breathing or swallowing
  • Fainting or feeling dizzy

Eye Problems in Patients With Diabetes

Contact your provider if you notice changes in vision.

Increased Heart Rate

Notify your provider if you experience a rapid heartbeat while at rest.

Mood or Behavioral Changes

Contact your provider if you experience new or worsening changes in mood or behavior.

Low Appetite and Dehydration Risk

Tirzepatide may reduce appetite. In some patients, reduced intake combined with nausea or diarrhea can increase the risk of dehydration. Drink fluids regularly and contact your provider if you are unable to keep fluids down.

Never Share Injection Devices

Do not share injection pens or syringes with another person. Sharing devices may increase the risk of infection.

Most Common Side Effects

  • Nausea
  • Diarrhea
  • Vomiting
  • Constipation
  • Stomach discomfort
  • Indigestion
  • Injection site reactions
  • Decreased appetite
  • Fatigue
  • Heartburn

These effects are often mild to moderate and may decrease as your body adjusts to treatment.

Important Treatment Instructions

  • Your provider should show you how to administer the injection before your first dose.
  • Use the medication exactly as prescribed.
  • Inject once per week on the same day each week.
  • Rotate injection sites each week.

If too much medication is taken, seek medical advice promptly or contact a poison control center.

Learn More

This summary provides general information about tirzepatide but does not include all available information about this medication.

Always follow the guidance of your healthcare provider and review the medication information provided with your prescription.

Your provider can help determine whether this treatment is appropriate for you.

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